ISA 2006 doesn't work on any version of windows 2008 Also ISA 2006 is 32bit application so it won't work on for example Windows 2003 X64 either. However you could virtualize it within Hyper-V for example.
MCTS, MCITP (SA,EA) MCP, MCSA:Security, MCSE:Security, CCNA, CCSA, CCSE, CCSE+ No matter how secure, there is always the human factor. http://www.phetios.com/
Win2008 64 & 32 not support to ISA 2004/2006 you should deploy the enhanced version of ISA is Forefront Threat Management Gatway Beta2. i have successfully deployed in my lab by the following steps: Step By Step installation of Forefront Threat Management Gateway (TMG) Beta 2: 1) Fresh Win2008 64bit machine, 32bit not supported .(Workgroup) 2) Download DotNet Framework 3.0 and install. 3) Add Features Win2008 like below: @Dotnet framework3.0. @Message Queuing. @Power Shell.
4) Join this Win2008 machine to your domain. (Domain Member) 5) Login as Domain Administrator on Win2008 machine. 6) Double click on the setup file ForeFrontTMGBeta2.exe. 7) During installation it will ask about Email Policy for Exchange2007 Edge Transport Server Role, just click ok.
8) Installation is proceed and completed. i m very thankfull to Mr.Tom Shider, who enable me to understand the ISA Server in better way, i got many help by his articles. a lot of thanks to Tom Shinder.