From: houston, texas, usa
Hmm...let's check some things. Start the ISA managment console.
I'm not in front of ISA right now so bear with me. You need to go the tab that let's you define "Client Address Sets", i believe it's under Polices or something similar. How many client address sets are there? The mail wizard should have created one for your exchange server, at the very least. If that's the only one listed, right click on it, choose properties, and add your IIS SMTP server's IP address to this client set. This should be all that's needed to get ya going.
If you see two sets, make sure there is one for your IIS machine, and verify it has the right addresses in it.
If you did see a client set for your IIS machine, and it did have the right IP address in there, we need to look at the "Protocol Rules" under "Access Policy".
Make sure the Mail Wizard created a rule that matches the client set for the IIS box. You should at least see the rule it created for your Exchange server. If you don't see a rule for your IIS machine (and you DID have a client set for your IIS machine), you will need to create a protocol rule to allow SMTP traffic to go out through ISA from the IIS box. Just model the rule after the one it created for the Exchange server.
Hope this helps, or if all the rules and client sets look kosher, we may have to look elsewhere. Either way, let us know
From: Brunswick, GA USA
Well, everything seems to be working fine now. Don't know what changed but it started working this morning. I had to tweak IIS just a bit as it could only send email to external domains, but all is well.